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RHO-ASSOCIATED KINASES
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DeCS
Descriptor
English
:
rho-Associated Kinases
Descriptor
Spanish
:
Quinasas Asociadas a rho
Descriptor
Portuguese
:
Quinases Associadas a rho
Synonyms
English
:
rho-Associated Kinase
Tree Number:
D08.811.913.696.620.682.700.814
D12.644.360.590
D12.776.476.595
Definition
English
:
A group of intracellular-signaling
serine
threonine
kinases that bind to
RHO GTP-BINDING PROTEINS
. They were originally found to mediate the effects of
rhoA GTP-BINDING PROTEIN
on the formation of
STRESS FIBERS
and
FOCAL ADHESIONS
.
Rho-associated kinases
have specificity for a variety of
substrates
including
MYOSIN-LIGHT-CHAIN PHOSPHATASE
and
LIM KINASES.
History Note
English
:
2008
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52746
Unique Identifier:
D054460
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS